Phylo Exercise

A motivating video on genomics:


The goal of this teaching item is to explore the DNA structure of genes and relate it to evolution. This is done through the use of a scientific discovery game, Phylo, that allows to perform sequence alignments in an intuitive manner. The results are latter put in perspective in a short report.


Play the game:

– play a few puzzles to get the functioning of the alignment interface; after 20 you will be able to enter the expert section (which is even more fun).


Write a report answering the following questions:

– what does the score corresponds to?

– do you think the scoring matrix should change as a function of the organisms evaluated? why?

[useful sources: (phylo)] (blastz)]

– Can you imagine how some mutations could have more/less influence on the phenotype than others?

Should they be more/less conserved through evolution?


Phylo Exercise by Antoine Taly and Jerome Waldispuhl est mis à disposition selon les termes de la licence Creative Commons Attribution – Partage dans les Mêmes Conditions 3.0 France.

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